CATH Classification

Domain Context

CATH Clusters

Superfamily Pseudouridine synthase
Functional Family Pseudouridine synthase

Enzyme Information

5.4.99.22
23S rRNA pseudouridine(2605) synthase.
based on mapping to UniProt P37765
23S rRNA uridine(2605) = 23S rRNA pseudouridine(2605).
-!- Pseudouridine synthase RluB converts uridine(2605) of 23S rRNA to pseudouridine.

UniProtKB Entries (1)

P37765
RLUB_ECOLI
Escherichia coli K-12
Ribosomal large subunit pseudouridine synthase B

PDB Structure

PDB 4LGT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
Czudnochowski, N., Ashley, G.W., Santi, D.V., Alian, A., Finer-Moore, J., Stroud, R.M.
Nucleic Acids Res.