CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.920
Functional Family transketolase isoform X2

Enzyme Information

2.2.1.1
Transketolase.
based on mapping to UniProt P29401
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.
-!- Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO(2) and R-CHOH-CO-CH(2)OH. -!- The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.

UniProtKB Entries (1)

P29401
TKT_HUMAN
Homo sapiens
Transketolase

PDB Structure

PDB 4KXY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Sub-angstrom-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate.
Ludtke, S., Neumann, P., Erixon, K.M., Leeper, F., Kluger, R., Ficner, R., Tittmann, K.
Nat Chem