CATH Classification

Domain Context

CATH Clusters

Superfamily Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain
Functional Family Cytosolic 5-nucleotidase 3-like

Enzyme Information

3.1.3.5
5'-nucleotidase.
based on mapping to UniProt Q9D020
A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
-!- Wide specificity for 5'-nucleotides.
3.1.3.91
7-methylguanosine nucleotidase.
based on mapping to UniProt Q9D020
(1) N(7)-methyl-GMP + H(2)O = N(7)-methyl-guanosine + phosphate. (2) CMP + H(2)O = cytidine + phosphate.
-!- The enzyme also has low activity with N(7)-methyl-GDP, producing N(7)-methyl-GMP. -!- Does not accept AMP or GMP, and has low activity with UMP.

UniProtKB Entries (1)

Q9D020
5NT3A_MOUSE
Mus musculus
Cytosolic 5'-nucleotidase 3A

PDB Structure

PDB 4KX3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of murine cytosolic 5'-nucleotidase III complexed with thymidine monophosphate
Bitto, E., Bingman, C.A., Grobosky, C.L.
To be Published