CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family

Enzyme Information

3.6.1.55
8-oxo-dGTP diphosphatase.
based on mapping to UniProt O35013
8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.
-!- This enzyme hydrolyzes the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. -!- It does not hydrolyze 2-hydroxy-dATP (cf. EC 3.6.1.56).

UniProtKB Entries (1)

O35013
YTKD_BACSU
Bacillus subtilis subsp. subtilis str. 168
Putative 8-oxo-dGTP diphosphatase YtkD

PDB Structure

PDB 4JZT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Bacillus subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates.
Piton, J., Larue, V., Thillier, Y., Dorleans, A., Pellegrini, O., Li de la Sierra-Gallay, I., Vasseur, J.J., Debart, F., Tisne, C., Condon, C.
Proc.Natl.Acad.Sci.USA