CATH Classification

Domain Context

CATH Clusters

Superfamily Enolase-like, N-terminal domain
Functional Family Hydrophobic dipeptide epimerase

Enzyme Information

5.1.1.22
4-hydroxyproline betaine 2-epimerase.
based on mapping to UniProt A1B198
(1) Trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine. (2) L-proline betaine = D-proline betaine.
-!- The enzyme, characterized from the bacteria Pelagibaca bermudensis and Paracoccus denitrificans, specifically catalyzes racemization of trans-4-hydroxy-L-proline betaine and L-proline betaine at the C-2 position.

UniProtKB Entries (1)

A1B198
HPBD_PARDP
Paracoccus denitrificans PD1222
4-hydroxyproline betaine 2-epimerase

PDB Structure

PDB 4J1O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine.
Kumar, R., Zhao, S., Vetting, M.W., Wood, B.M., Sakai, A., Cho, K., Solbiati, J., Almo, S.C., Sweedler, J.V., Jacobson, M.P., Gerlt, J.A., Cronan, J.E.
MBio