CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family Nudix hydrolase 2

Enzyme Information

3.6.1.17
Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical).
based on mapping to UniProt P50583
P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O = GTP + GMP.
-!- Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate (cf. EC 3.6.1.41).

UniProtKB Entries (1)

P50583
AP4A_HUMAN
Homo sapiens
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

PDB Structure

PDB 4IJX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of wild-type and mutant human Ap4A hydrolase.
Ge, H., Chen, X., Yang, W., Niu, L., Teng, M.
Biochem.Biophys.Res.Commun.