CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1460
Functional Family Gingipain R2

Enzyme Information

3.4.22.37
Gingipain R.
based on mapping to UniProt P95493
Hydrolysis of proteins and small molecule substrates, with a preference for Arg in P1.
-!- Strongly activated by glycine and stabilized by calcium. -!- Belongs to peptidase family C25.

UniProtKB Entries (1)

P95493
CPG2_PORGI
Porphyromonas gingivalis W83
Gingipain R2

PDB Structure

PDB 4IEF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Porphyromonas gingivalis Virulence Factor Gingipain RgpB Shows a Unique Zymogenic Mechanism for Cysteine Peptidases.
de Diego, I., Veillard, F.T., Guevara, T., Potempa, B., Sztukowska, M., Potempa, J., Gomis-Ruth, F.X.
J.Biol.Chem.