CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family DNA polymerase

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P13382
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P13382
DPOA_YEAST
Saccharomyces cerevisiae S288C
DNA polymerase alpha catalytic subunit A

PDB Structure

PDB 4FYD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism for priming DNA synthesis by yeast DNA Polymerase alpha
Perera, R.L., Torella, R., Klinge, S., Kilkenny, M.L., Maman, J.D., Pellegrini, L.
eLife