CATH Classification

Domain Context

CATH Clusters

Superfamily Complement Module, domain 1
Functional Family Mannan-binding lectin serine protease 2

Enzyme Information

3.4.21.104
Mannan-binding lectin-associated serine protease-2.
based on mapping to UniProt O00187
Selective cleavage after Arg-223 in complement component C2 (-Ser- Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).
-!- Mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine, on a wide range of microbial surfaces and is able to initiate activation of the lectin pathway of complement. -!- Displays C1s-like esterolytic activity (cf. EC 3.4.21.42). -!- It also cleaves C4 and C2 with efficiencies that are relatively higher than those of EC 3.4.21.42. -!- Belongs to peptidase family S1A.

UniProtKB Entries (1)

O00187
MASP2_HUMAN
Homo sapiens
Mannan-binding lectin serine protease 2

PDB Structure

PDB 4FXG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for activation of the complement system by component C4 cleavage.
Kidmose, R.T., Laursen, N.S., Dobo, J., Kjaer, T.R., Sirotkina, S., Yatime, L., Sottrup-Jensen, L., Thiel, S., Gal, P., Andersen, G.R.
Proc.Natl.Acad.Sci.USA