CATH Classification

Domain Context

CATH Clusters

Superfamily Integrase, C-terminal domain superfamily, retroviral
Functional Family Gag-Pol polyprotein

Enzyme Information

3.1.-.-
Acting on ester bonds.
based on mapping to UniProt P03354
3.4.23.-
Aspartic endopeptidases.
based on mapping to UniProt P03354
3.1.26.4
Ribonuclease H.
based on mapping to UniProt P03354
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
2.7.7.49
RNA-directed DNA polymerase.
based on mapping to UniProt P03354
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
2.7.7.-
Nucleotidyltransferases.
based on mapping to UniProt P03354
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P03354
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P03354
POL_RSVP
Rous sarcoma virus - Prague C
Gag-Pol polyprotein

PDB Structure

PDB 4FW2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A possible role for the asymmetric C-terminal domain dimer of Rous sarcoma virus integrase in viral DNA binding.
Shi, K., Pandey, K.K., Bera, S., Vora, A.C., Grandgenett, D.P., Aihara, H.
Plos One