CATH Classification

Domain Context

CATH Clusters

Superfamily Aldehyde Dehydrogenase; Chain A, domain 1
Functional Family Aldehyde dehydrogenase, mitochondrial

Enzyme Information

1.2.1.3
Aldehyde dehydrogenase (NAD(+)).
based on mapping to UniProt P05091
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
-!- Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. -!- Formerly EC 1.1.1.70.

UniProtKB Entries (1)

P05091
ALDH2_HUMAN
Homo sapiens
Aldehyde dehydrogenase, mitochondrial

PDB Structure

PDB 4FR8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Vascular Bioactivation of Nitroglycerin by Aldehyde Dehydrogenase-2: REACTION INTERMEDIATES REVEALED BY CRYSTALLOGRAPHY AND MASS SPECTROMETRY.
Lang, B.S., Gorren, A.C., Oberdorfer, G., Wenzl, M.V., Furdui, C.M., Poole, L.B., Mayer, B., Gruber, K.
J.Biol.Chem.