CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.60 | 4-Layer Sandwich |
|
3.60.15 | Metallo-beta-lactamase; Chain A |
|
3.60.15.10 | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
Domain Context
CATH Clusters
| Superfamily | Ribonuclease Z/Hydroxyacylglutathione hydrolase-like |
| Functional Family | Persulfide dioxygenase ETHE1, mitochondrial |
Enzyme Information
| 1.13.11.18 |
Persulfide dioxygenase.
based on mapping to UniProt O95571
S-sulfanylglutathione + O(2) + H(2)O = glutathione + sulfite + 2 H(+).
-!- Perthiols, formed spontaneously by interactions between thiols and elemental sulfur or sulfide, are the only acceptable substrate to the enzyme. -!- The sulfite that is formed by the enzyme can be further converted into sulfate, thiosulfate or S-sulfoglutathione (GSSO(3)(-)) non- enzymically.
|
UniProtKB Entries (1)
| O95571 |
ETHE1_HUMAN
Homo sapiens
Persulfide dioxygenase ETHE1, mitochondrial
|
PDB Structure
| PDB | 4CHL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.
Hum. Mol. Genet.
|