CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family hepatocyte growth factor activator

Enzyme Information

3.4.21.38
Coagulation factor XIIa.
based on mapping to UniProt P00748
Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.
-!- Also activates plasma prekallikrein and plasminogen. -!- Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00748
FA12_HUMAN
Homo sapiens
Coagulation factor XII

PDB Structure

PDB 4BDX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structure of the Fni-Egf-Like Tandem Domain of Coagulation Factor Xii Solved Using Siras.
Beringer, D.X., Kroon-Batenburg, L.M.J.
Acta Crystallogr.,Sect.F