CATH Classification

Domain Context

CATH Clusters

Superfamily Metalloproteases ("zincins"), catalytic domain like
Functional Family Botulinum neurotoxin type A

Enzyme Information

3.4.24.69
Bontoxilysin.
based on mapping to UniProt P0DPI1
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.

UniProtKB Entries (2)

P0DPI1
BXA1_CLOBH
Clostridium botulinum A str. Hall
Botulinum neurotoxin type A
O00161
SNP23_HUMAN
Homo sapiens
Synaptosomal-associated protein 23

PDB Structure

PDB 3ZUS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of Engineered Clostridium Botulinum Neurotoxin Derivatives
Masuyer, G., Stancombe, P., Chaddock, J.A., Acharya, K.R.
Acta Crystallogr.,Sect.F