CATH Classification

Domain Context

CATH Clusters

Superfamily Receptor L-domain
Functional Family Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P04626
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P04626
ERBB2_HUMAN
Homo sapiens
Receptor tyrosine-protein kinase erbB-2

PDB Structure

PDB 3WSQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Insights into HER2 signaling from step-by-step optimization of anti-HER2 antibodies.
Fu, W., Wang, Y., Zhang, Y., Xiong, L., Takeda, H., Ding, L., Xu, Q., He, L., Tan, W., Bethune, A.N., Zhou, L.
MAbs