CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.630 | Cytochrome p450 |
|
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
| Superfamily | Cytochrome P450 |
| Functional Family | Cholesterol 7-alpha-monooxygenase |
Enzyme Information
| 1.14.14.23 |
Cholesterol 7-alpha-monooxygenase.
based on mapping to UniProt P22680
Cholesterol + [reduced NADPH--hemoprotein reductase] + O(2) = 7-alpha- hydroxycholesterol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
-!- Catalyzes the first step in the biosynthesis of bile acids. -!- The direct electron donor to the enzyme is EC 1.6.2.4. -!- Formerly EC 1.14.13.17.
|
UniProtKB Entries (1)
| P22680 |
CP7A1_HUMAN
Homo sapiens
Cholesterol 7-alpha-monooxygenase
|
PDB Structure
| PDB | 3V8D |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of human CYP7A1 in complex with 7-ketocholesterol
To be Published
|