CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Tryptase beta-2

Enzyme Information

3.4.21.59
Tryptase.
based on mapping to UniProt P20231
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.
-!- Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. -!- Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P20231
TRYB2_HUMAN
Homo sapiens
Tryptase beta-2

PDB Structure

PDB 3V7T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A beta-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity
Liang, G., Choi-Sledeski, Y.M., Shum, P., Chen, X., Poli, G.B., Kumar, V., Minnich, A., Wang, Q., Tsay, J., Sides, K., Kang, J., Zhang, Y.
Bioorg.Med.Chem.Lett.