CATH Classification

Domain Context

CATH Clusters

Superfamily DNA polymerase, thumb domain
Functional Family DNA polymerase

Enzyme Information

4.2.99.-
Other carbon-oxygen lyases.
based on mapping to UniProt P06766
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P06766
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P06766
DPOLB_RAT
Rattus norvegicus
DNA polymerase beta

PDB Structure

PDB 3V72
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Unfavorable Electrostatic and Steric Interactions in DNA Polymerase beta E295K Mutant Interfere with the Enzyme s Pathway
Li, Y., Gridley, C.L., Jaeger, J., Sweasy, J.B., Schlick, T.
J.Am.Chem.Soc.