1 keywords

CATH Domain 3v5wG00

CATH Classification

Level CATH Code Description
Class 4 Few Secondary Structures
Architecture 4.10 Irregular
Topology 4.10.260 G Protein Gi Gamma 2
Homologous Superfamily 4.10.260.10 Transducin (heterotrimeric G protein), gamma chain

Domain Context

CATH Clusters

Superfamily Transducin (heterotrimeric G protein), gamma chain
Functional Family

Enzyme Information

UniProtKB Entries (2)

P63212
GBG2_BOVIN
Bos taurus
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
P25098
ARBK1_HUMAN
Homo sapiens
Beta-adrenergic receptor kinase 1

PDB Structure

PDB 3V5W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.
Thal, D.M., Homan, K.T., Chen, J., Wu, E.K., Hinkle, P.M., Huang, Z.M., Chuprun, J.K., Song, J., Gao, E., Cheung, J.Y., Sklar, L.A., Koch, W.J., Tesmer, J.J.
Acs Chem.Biol.