CATH Domain 3u88D00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.930	Transcription Elongation Factor S-II; Chain A
	1.20.930.10	Conserved domain common to transcription factors TFIIS, elongin A, CRSP70

Domain Context

CATH Clusters

Superfamily	Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
Functional Family	PC4 and SFRS1-interacting protein-like isoform X1

Enzyme Information

UniProtKB Entries (1)

KMT2A_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase 2A

PDB Structure

PDB	3U88
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Huang, J., Gurung, B., Wan, B., Matkar, S., Veniaminova, N.A., Wan, K., Merchant, J.L., Hua, X., Lei, M. Nature