CATH Classification

Domain Context

CATH Clusters

Superfamily MutM-like, N-terminal
Functional Family Putative Formamidopyrimidine-DNA glycosylase

Enzyme Information

4.2.99.18
DNA-(apurinic or apyrimidinic site) lyase.
based on mapping to UniProt O80358
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
3.2.2.23
DNA-formamidopyrimidine glycosylase.
based on mapping to UniProt O80358
Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.
-!- May play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents. -!- Also involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA.

UniProtKB Entries (1)

O80358
FPG_ARATH
Arabidopsis thaliana
Formamidopyrimidine-DNA glycosylase

PDB Structure

PDB 3TWM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine.
Duclos, S., Aller, P., Jaruga, P., Dizdaroglu, M., Wallace, S.S., Doublie, S.
Dna Repair