CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.70.80
Functional Family OTU domain-containing protein 5 isoform X2

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt Q96G74
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Q96G74
OTUD5_HUMAN
Homo sapiens
OTU domain-containing protein 5

PDB Structure

PDB 3TMP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Phosphorylation-dependent activity of the deubiquitinase DUBA.
Huang, O.W., Ma, X., Yin, J., Flinders, J., Maurer, T., Kayagaki, N., Phung, Q., Bosanac, I., Arnott, D., Dixit, V.M., Hymowitz, S.G., Starovasnik, M.A., Cochran, A.G.
Nat.Struct.Mol.Biol.