CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.320.10
Functional Family

Enzyme Information

3.1.11.3
Exodeoxyribonuclease (lambda-induced).
based on mapping to UniProt P03697
Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates.
-!- Preference for double-stranded DNA. -!- Does not attack single-strand breaks. -!- Similar enzymes: T4, T5 and T7 exonucleases, mammalian DNase IV. -!- Formerly EC 3.1.4.28.

UniProtKB Entries (1)

P03697
EXO_LAMBD
Escherichia virus Lambda
Exonuclease

PDB Structure

PDB 3SLP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of {lambda} exonuclease in complex with DNA suggest an electrostatic ratchet mechanism for processivity.
Zhang, J., McCabe, K.A., Bell, C.E.
Proc.Natl.Acad.Sci.USA