CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family L-ornithine N(5)-monooxygenase

Enzyme Information

1.14.13.195
L-ornithine N(5)-monooxygenase (NADPH).
based on mapping to UniProt Q51548
L-ornithine + NADPH + O(2) = N(5)-hydroxy-L-ornithine + NADP(+) + H(2)O.
-!- The enzyme is involved in biosynthesis of N(5)-hydroxy-L-ornithine, N(5)-formyl-N(5)-hydroxy-L-ornithine or N(5)-acetyl-N(5)-hydroxy-L- ornithine. -!- These nonproteinogenic amino acids are building blocks of siderophores produced by some bacteria (e.g. Streptomyces coelicolor, Saccharopolyspora erythraea and Pseudomonas aeruginosa). -!- The enzyme is specific for NADPH. -!- Cf. EC 1.14.13.196.

UniProtKB Entries (1)

Q51548
PVDA_PSEAE
Pseudomonas aeruginosa PAO1
L-ornithine N(5)-monooxygenase

PDB Structure

PDB 3S61
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Two Structures of an N-Hydroxylating Flavoprotein Monooxygenase: ORNITHINE HYDROXYLASE FROM PSEUDOMONAS AERUGINOSA.
Olucha, J., Meneely, K.M., Chilton, A.S., Lamb, A.L.
J.Biol.Chem.