CATH Classification

Domain Context

CATH Clusters

Superfamily YjeF N-terminal domain
Functional Family NAD(P)H-hydrate epimerase

Enzyme Information

5.1.99.6
NAD(P)H-hydrate epimerase.
based on mapping to UniProt Q8K4Z3
(1) (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide. (2) (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = (6S)-6-beta-hydroxy-1,4,5,6- tetrahydronicotinamide-adenine dinucleotide phosphate.
-!- The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate. -!- Its physiological role is to convert the (R) forms to the (S) forms, which could then be restored to active dinucleotides by EC 4.2.1.93.

UniProtKB Entries (1)

Q8K4Z3
NNRE_MOUSE
Mus musculus
NAD(P)H-hydrate epimerase

PDB Structure

PDB 3ROE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification of unknown protein function using metabolite cocktail screening.
Shumilin, I.A., Cymborowski, M., Chertihin, O., Jha, K.N., Herr, J.C., Lesley, S.A., Joachimiak, A., Minor, W.
Structure