1 keywords

CATH Domain 3q91D00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.79 Nucleoside Triphosphate Pyrophosphohydrolase
Homologous Superfamily 3.90.79.10 Nucleoside Triphosphate Pyrophosphohydrolase

Domain Context

CATH Clusters

Superfamily Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family Uridine diphosphate glucose pyrophosphatase

Enzyme Information

3.6.1.45
UDP-sugar diphosphatase.
based on mapping to UniProt O95848
UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate.
-!- UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. -!- Thus, this enzyme has a specificity distinct from that of EC 3.6.1.21. -!- Some but not all enzymes of this class also appear to have EC 3.1.3.5 activity.

UniProtKB Entries (1)

O95848
NUD14_HUMAN
Homo sapiens
Uridine diphosphate glucose pyrophosphatase

PDB Structure

PDB 3Q91
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14)
Tresaugues, L., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Ekblad, T., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kol, S., Kotenyova, T., Kouznetsova, E., Moche, M., Nyman, T., Persson, C., Schuler, H., Schutz, P., Thorsell, A.G., Van Der Berg, S., Wahlberg, E., Weigelt, J., Welin, M., Nordlund, P.
To be Published