CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.310 | TATA-Binding Protein |
|
3.30.310.80 | Kinase associated domain 1, KA1 |
Domain Context
CATH Clusters
| Superfamily | Kinase associated domain 1, KA1 |
| Functional Family | Non-specific serine/threonine protein kinase |
Enzyme Information
| 2.7.11.26 |
[Tau protein] kinase.
based on mapping to UniProt Q9P0L2
ATP + [tau protein] = ADP + [tau protein] phosphate.
-!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.
|
| 2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q9P0L2
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
UniProtKB Entries (1)
| Q9P0L2 |
MARK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase MARK1
|
PDB Structure
| PDB | 3OSE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Kinase Associated-1 Domains Drive MARK/PAR1 Kinases to Membrane Targets by Binding Acidic Phospholipids.
Cell(Cambridge,Mass.)
|