CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.11710 | Cyclodipeptide synthase |
Domain Context
CATH Clusters
| Superfamily | Cyclodipeptide synthase |
| Functional Family | Cyclo(L-leucyl-L-phenylalanyl) synthase |
Enzyme Information
| 2.3.2.20 |
Cyclo(L-leucyl-L-phenylalanyl) synthase.
based on mapping to UniProt Q8GED7
L-leucyl-tRNA(Leu) + L-phenylalanyl-tRNA(Phe) = tRNA(Leu) + tRNA(Phe) + cyclo(L-leucyl-L-phenylalanyl).
-!- The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the L-phenylalanine residue. -!- The protein, found in the bacterium Streptomyces noursei, also forms cyclo(L-phenylalanyl-L-phenylalanyl), cyclo(L-methionyl-L- phenylalanyl), cyclo(L-phenylalanyl-L-tyrosyl) and cyclo(L-methionyl- L-tyrosyl).
|
UniProtKB Entries (1)
| Q8GED7 |
CLPS_STRNR
Streptomyces noursei
Cyclo(L-leucyl-L-phenylalanyl) synthase
|
PDB Structure
| PDB | 3OQV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Cyclodipeptide synthases, a family of class-I aminoacyl-tRNA synthetase-like enzymes involved in non-ribosomal peptide synthesis.
Nucleic Acids Res.
|