CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.230 | Cytochrome p450-Terp; domain 2 | |
1.10.230.10 | Cytochrome P450-Terp, domain 2 |
Domain Context
CATH Clusters
Superfamily | Cytochrome P450-Terp, domain 2 |
Functional Family | Citrate synthase |
Enzyme Information
2.3.3.16 |
Citrate synthase (unknown stereospecificity).
based on mapping to UniProt Q56063
Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA.
-!- This entry has been included to accommodate those citrate synthases for which the stereospecificity with respect to C(2) of oxaloacetate has not been established (cf. EC 2.3.3.1 and EC 2.3.3.3).
|
2.3.3.5 |
2-methylcitrate synthase.
based on mapping to UniProt Q56063
Propanoyl-CoA + H(2)O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3- tricarboxylate + CoA.
-!- The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. -!- The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC 2.3.3.1. -!- Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate. -!- Formerly EC 4.1.3.31.
|
UniProtKB Entries (1)
Q56063 |
PRPC_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
2-methylcitrate synthase
|
PDB Structure
PDB | 3O8J |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structure of Salmonella typhimurium 2-methylcitrate synthase: Insights on domain movement and substrate specificity
J.Struct.Biol.
|