CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450-Terp, domain 2
Functional Family Citrate synthase

Enzyme Information

2.3.3.16
Citrate synthase (unknown stereospecificity).
based on mapping to UniProt Q56063
Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA.
-!- This entry has been included to accommodate those citrate synthases for which the stereospecificity with respect to C(2) of oxaloacetate has not been established (cf. EC 2.3.3.1 and EC 2.3.3.3).
2.3.3.5
2-methylcitrate synthase.
based on mapping to UniProt Q56063
Propanoyl-CoA + H(2)O + oxaloacetate = (2S,3S)-2-hydroxybutane-1,2,3- tricarboxylate + CoA.
-!- The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. -!- The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC 2.3.3.1. -!- Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate. -!- Formerly EC 4.1.3.31.

UniProtKB Entries (1)

Q56063
PRPC_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
2-methylcitrate synthase

PDB Structure

PDB 3O8J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of Salmonella typhimurium 2-methylcitrate synthase: Insights on domain movement and substrate specificity
Chittori, S., Savithri, H.S., Murthy, M.R.N.
J.Struct.Biol.