CATH Classification

Domain Context

CATH Clusters

Superfamily EF-hand
Functional Family Calmodulin 1

Enzyme Information

2.7.11.18
[Myosin light-chain] kinase.
based on mapping to UniProt P11799
ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.
-!- Requires calmodulin for activity. -!- The 20 kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, more slowly. -!- Formerly EC 2.7.1.117.

UniProtKB Entries (3)

P11799
MYLK_CHICK
Gallus gallus
Myosin light chain kinase, smooth muscle
P0DP23
CALM1_HUMAN
Homo sapiens
Calmodulin-1
P42212
GFP_AEQVI
Aequorea victoria
Green fluorescent protein

PDB Structure

PDB 3O78
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of Ca2+ sensor Case16 reveals the mechanism of reaction to low Ca2+ concentrations
Leder, L., Stark, W., Freuler, F., Marsh, M., Meyerhofer, M., Stettler, T., Mayr, L.M., Britanova, O.V., Strukova, L.A., Chudakov, D.M., Souslova, E.A.
Sensors (Basel)