CATH Classification

Domain Context

CATH Clusters

Superfamily Beta Polymerase, domain 2
Functional Family non-canonical poly(A) RNA polymerase PAPD5

Enzyme Information

2.7.7.19
Polynucleotide adenylyltransferase.
based on mapping to UniProt P53632
ATP + RNA(n) = diphosphate + RNA(n+1).
-!- Also acts slowly with CTP. -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group. -!- See also EC 2.7.7.6.

UniProtKB Entries (1)

P53632
PAP2_YEAST
Saccharomyces cerevisiae S288C
Poly(A) RNA polymerase protein 2

PDB Structure

PDB 3NYB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and function of the polymerase core of TRAMP, a RNA surveillance complex.
Hamill, S., Wolin, S.L., Reinisch, K.M.
Proc.Natl.Acad.Sci.USA