CATH Domain 3nr6B00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.70	Cathepsin D, subunit A; domain 1
	2.40.70.10	Acid Proteases

Domain Context

CATH Clusters

Superfamily	Acid Proteases
Functional Family	Gag-Pol polyprotein

Enzyme Information

2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt A1Z651 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
2.7.7.49	RNA-directed DNA polymerase. based on mapping to UniProt A1Z651 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
3.1.26.4	Ribonuclease H. based on mapping to UniProt A1Z651 Endonucleolytic cleavage to 5'-phosphomonoester. -!- Acts on RNA-DNA hybrids.
2.7.7.-	Nucleotidyltransferases. based on mapping to UniProt A1Z651
3.4.23.-	Aspartic endopeptidases. based on mapping to UniProt A1Z651
3.1.-.-	Acting on ester bonds. based on mapping to UniProt A1Z651

UniProtKB Entries (1)

POL_XMRV6

Xenotropic MuLV-related virus VP62

Gag-Pol polyprotein

PDB Structure

PDB	3NR6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of XMRV protease differs from the structures of other retropepsins. Li, M., Dimaio, F., Zhou, D., Gustchina, A., Lubkowski, J., Dauter, Z., Baker, D., Wlodawer, A. Nat.Struct.Mol.Biol.