CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Glutathione S-transferase theta-2B

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P0CG30
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P0CG30
GSTT2_HUMAN
Homo sapiens
Glutathione S-transferase theta-2B

PDB Structure

PDB 3LJR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site.
Rossjohn, J., McKinstry, W.J., Oakley, A.J., Verger, D., Flanagan, J., Chelvanayagam, G., Tan, K.L., Board, P.G., Parker, M.W.
Structure