CATH Classification

Domain Context

CATH Clusters

Superfamily Macrophage Migration Inhibitory Factor
Functional Family Macrophage migration inhibitory factor

Enzyme Information

5.3.3.12
L-dopachrome isomerase.
based on mapping to UniProt P14174
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
-!- Stereospecific for L-dopachrome (5,6-dioxo-2,3-5,6-tetrahydroindole- 2-carboxylate). -!- Dopachrome methyl ester is a substrate, but dopaminochrome (2,3- dihydroxyindolyl-5,6-quinone) is not (see also EC 4.1.1.84).
5.3.2.1
Phenylpyruvate tautomerase.
based on mapping to UniProt P14174
Keto-phenylpyruvate = enol-phenylpyruvate.
-!- Also acts on other arylpyruvates.

UniProtKB Entries (1)

P14174
MIF_HUMAN
Homo sapiens
Macrophage migration inhibitory factor

PDB Structure

PDB 3L5P
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site.
McLean, L.R., Zhang, Y., Li, H., Choi, Y.M., Han, Z., Vaz, R.J., Li, Y.
Bioorg.Med.Chem.Lett.