CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family Peptidylprolyl isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q43207
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q43207
FKB70_WHEAT
Triticum aestivum
70 kDa peptidyl-prolyl isomerase

PDB Structure

PDB 3JYM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domain
Unger, T., Dym, O., Albeck, S., Jacobovitch, Y., Bernehim, R., Marom, D., Pisanty, O., Breiman, A.
J.STRUCT.FUNCT.GENOM.