CATH Classification

Domain Context

CATH Clusters

Superfamily Aldehyde Dehydrogenase; Chain A, domain 2
Functional Family N-succinylglutamate 5-semialdehyde dehydrogenase

Enzyme Information

1.2.1.71
Succinylglutamate-semialdehyde dehydrogenase.
based on mapping to UniProt O50174
N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L- glutamate + NADH.
-!- This is the fourth enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine. -!- This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. -!- The five enzymes involved in this pathway are EC 2.3.1.109, EC 3.5.3.23, EC 2.6.1.11, EC 1.2.1.71 and EC 3.5.1.96.

UniProtKB Entries (1)

O50174
ASTD_PSEAE
Pseudomonas aeruginosa PAO1
N-succinylglutamate 5-semialdehyde dehydrogenase

PDB Structure

PDB 3JU8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Succinylglutamic Semialdehyde Dehydrogenase from Pseudomonas aeruginosa
Kim, Y., Li, H., Buck, K., Joachimiak, A.
To be Published