CATH Domain 3jtlL00
|3.60.20||Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1|
|184.108.40.206||Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1|
|Superfamily||Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1|
|Functional Family||Proteasome subunit beta|
Proteasome endopeptidase complex.
based on mapping to UniProt P28061
Cleavage of peptide bonds with very broad specificity.
-!- A 20-S protein composed of 28 subunits arranged in four rings of seven. -!- The outer rings are composed of alpha subunits, but the beta subunits forming the inner rings are responsible for peptidase activity. -!- In eukaryotic organisms there are up to seven different types of beta subunits, three of which may carry the N-terminal threonine residues that are the nucleophiles in catalysis, and show different specificities. -!- The molecule is barrel-shaped, and the active sites are on the inner surfaces. -!- Terminal apertures restrict access of substrates to the active sites. -!- Inhibited by mercurial reagents and some inhibitors of serine endopeptidases. -!- Belongs to peptidase family T1. -!- Formerly EC 220.127.116.11, EC 18.104.22.168 and EC 22.214.171.124.
UniProtKB Entries (2)
Proteasome activator protein PA26
Thermoplasma acidophilum DSM 1728
Proteasome subunit alpha
Structural Models for Interactions between the 20S proteasome and its PAN/19S activators.