CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.630 | Aminopeptidase | |
3.40.630.170 |
Domain Context
CATH Clusters
Superfamily | 3.40.630.170 |
Functional Family | Glycylpeptide N-tetradecanoyltransferase |
Enzyme Information
2.3.1.97 |
Glycylpeptide N-tetradecanoyltransferase.
based on mapping to UniProt P30419
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal- N-tetradecanoylglycyl-[protein].
-!- The enzyme catalyzes the transfer of myristic acid from myristoyl-CoA to the amino group of the N-terminal glycine residue in a variety of eukaryotic proteins. -!- It uses an ordered Bi Bi reaction in which myristoyl-CoA binds to the enzyme prior to the binding of the peptide substrate, and CoA release precedes the release of the myristoylated peptide. -!- The enzyme from yeast is profoundly affected by amino acids further from the N-terminus, and is particularly stimulated by a serine residue at position 5.
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UniProtKB Entries (1)
P30419 |
NMT1_HUMAN
Homo sapiens
Glycylpeptide N-tetradecanoyltransferase 1
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PDB Structure
PDB | 3IU2 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90096
To be Published
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