CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Aklavinone 12-hydroxylase RdmE

Enzyme Information

1.14.13.180
Aklavinone 12-hydroxylase.
based on mapping to UniProt Q54530
Aklavinone + NADPH + O(2) = epsilon-rhodomycinone + NADP(+) + H(2)O.
-!- The enzymes from the Gram-positive bacteria Streptomyces peucetius and Streptomyces purpurascens participate in the biosynthesis of daunorubicin, doxorubicin and rhodomycins.

UniProtKB Entries (1)

Q54530
DNRF_STREF
Streptomyces purpurascens
Aklavinone 12-hydroxylase RdmE

PDB Structure

PDB 3IHG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis.
Lindqvist, Y., Koskiniemi, H., Jansson, A., Sandalova, T., Schnell, R., Liu, Z., Mantsala, P., Niemi, J., Schneider, G.
J.Mol.Biol.