CATH Domain 3ihgC01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.50	3-Layer(bba) Sandwich
	3.50.50	FAD/NAD(P)-binding domain
	3.50.50.60	FAD/NAD(P)-binding domain

Domain Context

CATH Clusters

Superfamily	FAD/NAD(P)-binding domain
Functional Family	Aklavinone 12-hydroxylase RdmE

Enzyme Information

1.14.13.180

Aklavinone 12-hydroxylase.

based on mapping to UniProt Q54530

Aklavinone + NADPH + O(2) = epsilon-rhodomycinone + NADP(+) + H(2)O.

-!- The enzymes from the Gram-positive bacteria Streptomyces peucetius and Streptomyces purpurascens participate in the biosynthesis of daunorubicin, doxorubicin and rhodomycins.

UniProtKB Entries (1)

Q54530

DNRF_STREF

Streptomyces purpurascens

Aklavinone 12-hydroxylase RdmE

PDB Structure

PDB	3IHG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis. Lindqvist, Y., Koskiniemi, H., Jansson, A., Sandalova, T., Schnell, R., Liu, Z., Mantsala, P., Niemi, J., Schneider, G. J.Mol.Biol.