CATH Domain 3hrdH02
|1.10.150||DNA polymerase; domain 1|
|Functional Family||Carbon monoxide dehydrogenase, small subunit|
based on mapping to UniProt Q0QLF3
Nicotinate + H(2)O + NADP(+) = 6-hydroxynicotinate + NADPH.
-!- The enzyme is capable of acting on a variety of nicotinate analogs to varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3- dicarboxylate, trigonelline and 6-methylnicotinate. -!- The enzyme from Clostridium barkeri also possesses a catalytically essential, labile selenium that can be removed by reaction with cyanide. -!- Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. -!- Other enzymes involved in this pathway are EC 22.214.171.124, EC 126.96.36.199, EC 188.8.131.521, EC 184.108.40.206, EC 220.127.116.11, EC 18.104.22.168 and EC 22.214.171.124. -!- Formerly EC 126.96.36.199.
UniProtKB Entries (1)
Nicotinate dehydrogenase large molybdopterin subunit
The Mo-Se active site of nicotinate dehydrogenase