CATH Classification

Domain Context

CATH Clusters

Superfamily Isoleucyl-tRNA Synthetase; Domain 1
Functional Family Methionine--tRNA ligase

Enzyme Information

6.1.1.10
Methionine--tRNA ligase.
based on mapping to UniProt P00959
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl- tRNA(Met).
-!- In those organisms producing N-formylmethionyl-tRNA(fMet) for translation initiation, this enzyme also recognizes the initiator tRNA(fMet) and catalyzes the formation of L-methionyl-tRNA(fMet), the substrate for EC 2.1.2.9.

UniProtKB Entries (1)

P00959
SYM_ECOLI
Escherichia coli K-12
Methionine--tRNA ligase

PDB Structure

PDB 3H9C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Switching from an induced-fit to a lock-and-key mechanism in an aminoacyl-tRNA synthetase with modified specificity.
Schmitt, E., Tanrikulu, I.C., Yoo, T.H., Panvert, M., Tirrell, D.A., Mechulam, Y.
J.Mol.Biol.