CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family L-lactate dehydrogenase A chain

Enzyme Information

1.1.1.27
L-lactate dehydrogenase.
based on mapping to UniProt P13491
(S)-lactate + NAD(+) = pyruvate + NADH.
-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

UniProtKB Entries (1)

P13491
LDHA_RABIT
Oryctolagus cuniculus
L-lactate dehydrogenase A chain

PDB Structure

PDB 3H3F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Modeling of isotope effects on binding oxamate to lactic dehydrogenase
Swiderek, K., Panczakiewicz, A., Bujacz, A., Bujacz, G., Paneth, P.
J.Phys.Chem.B