CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.505 | SHC Adaptor Protein |
|
3.30.505.10 | SH2 domain |
Domain Context
CATH Clusters
| Superfamily | SH2 domain |
| Functional Family | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma |
Enzyme Information
| 3.1.4.11 |
Phosphoinositide phospholipase C.
based on mapping to UniProt P10686
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.
|
UniProtKB Entries (2)
| P10686 |
PLCG1_RAT
Rattus norvegicus
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
|
| P11362 |
FGFR1_HUMAN
Homo sapiens
Fibroblast growth factor receptor 1
|
PDB Structure
| PDB | 3GQI |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
Cell(Cambridge,Mass.)
|