CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.40 | Immunoglobulin-like |
|
2.60.40.150 | C2 domain |
Domain Context
CATH Clusters
| Superfamily | C2 domain |
| Functional Family | Kinase C alpha type |
Enzyme Information
| 2.7.11.13 |
Protein kinase C.
based on mapping to UniProt P05696
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| P05696 |
KPCA_RAT
Rattus norvegicus
Protein kinase C alpha type
|
PDB Structure
| PDB | 3GPE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and mechanistic insights into the association of PKCalpha-C2 domain to PtdIns(4,5)P2.
Proc.Natl.Acad.Sci.USA
|