CATH Classification

Domain Context

CATH Clusters

Superfamily Translation factors
Functional Family NADPH--cytochrome P450 reductase

Enzyme Information

1.6.2.4
NADPH--hemoprotein reductase.
based on mapping to UniProt P16435
NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
-!- This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. -!- It also reduces cytochrome b5 and cytochrome c. -!- The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
1.6.2.4
NADPH--hemoprotein reductase.
based on mapping to UniProt P16603
NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
-!- This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. -!- It also reduces cytochrome b5 and cytochrome c. -!- The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.

UniProtKB Entries (2)

P16435
NCPR_HUMAN
Homo sapiens
NADPH--cytochrome P450 reductase
P16603
NCPR_YEAST
Saccharomyces cerevisiae S288C
NADPH--cytochrome P450 reductase

PDB Structure

PDB 3FJO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the open conformation of a functional chimeric NADPH cytochrome P450 reductase
Aigrain, L., Pompon, D., Morera, S., Truan, G.
Embo Rep.