CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.970
Functional Family Ubiquinone-dependent pyruvate dehydrogenase

Enzyme Information

1.2.5.1
Pyruvate dehydrogenase (quinone).
based on mapping to UniProt P07003
Pyruvate + ubiquinone + H(2)O = acetate + CO(2) + ubiquinol.
-!- This bacterial enzyme is located on the inner surface of the cytoplasmic membrane and coupled to the respiratory chain via ubiquinone. -!- Does not accept menaquinone. -!- Activity is greatly enhanced by lipids. -!- Requires thiamine diphosphate. -!- The enzyme can also form acetoin.

UniProtKB Entries (1)

P07003
POXB_ECOLI
Escherichia coli K-12
Pyruvate dehydrogenase [ubiquinone]

PDB Structure

PDB 3EYA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli.
Neumann, P., Weidner, A., Pech, A., Stubbs, M.T., Tittmann, K.
Proc.Natl.Acad.Sci.USA