CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.920
Functional Family Pyruvate dehydrogenase E1 beta subunit

Enzyme Information

1.2.4.1
Pyruvate dehydrogenase (acetyl-transferring).
based on mapping to UniProt P11177
Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
-!- It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex in which it is bound to a core of molecules of EC 2.3.1.12, which also binds multiple copies of EC 1.8.1.4. -!- It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.

UniProtKB Entries (1)

P11177
ODPB_HUMAN
Homo sapiens
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

PDB Structure

PDB 3EXF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.
Kato, M., Wynn, R.M., Chuang, J.L., Tso, S.C., Machius, M., Li, J., Chuang, D.T.
Structure