CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.50 | Rossmann fold | |
3.40.50.920 |
Domain Context
CATH Clusters
Superfamily | 3.40.50.920 |
Functional Family | Pyruvate dehydrogenase E1 beta subunit |
Enzyme Information
1.2.4.1 |
Pyruvate dehydrogenase (acetyl-transferring).
based on mapping to UniProt P11177
Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
-!- It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex in which it is bound to a core of molecules of EC 2.3.1.12, which also binds multiple copies of EC 1.8.1.4. -!- It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.
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UniProtKB Entries (1)
P11177 |
ODPB_HUMAN
Homo sapiens
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
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PDB Structure
PDB | 3EXF |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.
Structure
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