CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.287.280
Functional Family DNA-directed RNA polymerase

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P00573
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P00573
RPOL_BPT7
Enterobacteria phage T7
T7 RNA polymerase

PDB Structure

PDB 3E2E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of a transcribing t7 RNA polymerase in transition from initiation to elongation
Durniak, K.J., Bailey, S., Steitz, T.A.
Science