CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.630 | Cytochrome p450 |
|
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
| Superfamily | Cytochrome P450 |
| Functional Family | vitamin D 25-hydroxylase isoform X1 |
Enzyme Information
| 1.14.14.24 |
Vitamin D 25-hydroxylase.
based on mapping to UniProt Q6VVX0
Calciol + O(2) + [reduced NADPH--hemoprotein reductase] = calcidiol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
-!- A microsomal enzyme isolated from human and mouse liver that bioactivates vitamin D(3). -!- While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) are able to catalyze the reaction in vitro, only CYP2R1 is thought to catalyze the reaction in humans in vivo. -!- The direct electron donor to the enzyme is EC 1.6.2.4. -!- Formerly EC 1.14.13.159.
|
UniProtKB Entries (1)
| Q6VVX0 |
CP2R1_HUMAN
Homo sapiens
Vitamin D 25-hydroxylase
|
PDB Structure
| PDB | 3DL9 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of CYP2R1 in complex with 1-alpha-hydroxy-vitamin D2.
To be Published
|