CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Ribosomal RNA large subunit methyltransferase I

Enzyme Information

2.1.1.191
23S rRNA (cytosine(1962)-C(5))-methyltransferase.
based on mapping to UniProt P75876
S-adenosyl-L-methionine + cytosine(1962) in 23S rRNA = S-adenosyl-L- homocysteine + 5-methylcytosine(1962) in 23S rRNA.
-!- The enzyme specifically methylates cytosine(1962) at C(5) in 23S rRNA.

UniProtKB Entries (1)

P75876
RLMI_ECOLI
Escherichia coli K-12
Ribosomal RNA large subunit methyltransferase I

PDB Structure

PDB 3C0K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes
Sunita, S., Tkaczuk, K.L., Purta, E., Kasprzak, J.M., Douthwaite, S., Bujnicki, J.M., Sivaraman, J.
J.Mol.Biol.